Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This is certainly an impurity connected to bortezomib, a proteasome inhibitor used in the cure of numerous myeloma. Its synthesis or review is crucial for ensuring the purity and basic safety from the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-seven): A precursor from the synthesis of abiraterone acetate, a drug Employed in the treatment of prostate most cancers by inhibiting androgen generation.
Imatinib Intermediate (CAS NO. 152460-10-1): A important compound in the synthesis of imatinib, a drug that targets distinct forms of cancer, which include Persistent myelogenous leukemia (CML).
Docetaxel Intermediate: A compound Employed in the synthesis of docetaxel, a chemotherapy medication that treats several cancers like breast, lung, and prostate most cancers.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, 8): They are intermediates from the synthesis of gemcitabine, an anti-cancer drug. Their review is significant for optimizing the creation procedure and guaranteeing high purity.
Lapatinib Intermediate (CAS NO. 231278-84-five): Lapatinib is employed to deal with breast most cancers, and these intermediates are involved in its creation.
Fulvestrant Intermediates: Fulvestrant is an estrogen receptor antagonist Utilized in the cure of breast most cancers. Numerous CAS NO. 875573-63-0 intermediates help in the synthesis of the drug.
Paclitaxel Side Chain Acid (CAS NO. 949023-16-nine): This intermediate is Employed in the synthesis of paclitaxel, a chemotherapy drug effective in managing cancers which include ovarian, breast, and lung cancer.
three. Other Notable Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-3): A chemotherapy drug used in the remedy of colorectal cancer and compact mobile lung cancer.
three-Amino-1-hydroxyadamantane (CAS 702-eighty two-nine): This compound is involved with the synthesis of adamantane derivatives, which have several purposes, such as antiviral Qualities.
Vildagliptin Intermediates: Used in the production of vildagliptin, an oral drug for sort 2 diabetes that inhibits the enzyme DPP-4 to control blood sugar levels.
four. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-one): This compound is involved with the synthesis of varied gluconic acid derivatives, which might be Employed in foodstuff, pharmaceutical, and industrial apps.
Canagliflozin Intermediate 17b)-7-[9-[(4 2: A precursor while in the synthesis of canagliflozin, a medication utilised to handle sort 2 diabetic issues by inhibiting sodium-glucose co-transporter two (SGLT2).